Mutambudzi’s research focus is on chronic disease and occupational epidemiology. Much of her research has largely been directed towards the use of longitudinal data to assess disparities in morbidity, disability, and mortality, with particular interest in onset and progression of chronic diseases, work-related health outcomes, and social determinants of health in vulnerable populations and older adults in Europe and the U.S. She has published extensively in peer-reviewed journals including the European Journal of Ageing, Journal of Gerontology: Medical Science, and the Journal of Occupational and Environmental Medicine, among many others. She has presented at the International Union for the Scientific Study of Population (IUSSP), Epidemiology in Occupation Health Conference (EPICOH), and the Population Association of America (PAA).

Mutambudzi is the 2020 recipient of the Kammer Emmett Award from the American College of Occupational and Environmental Medicine (ACOEM) for the most outstanding article published in the Journal of Occupational and Environmental Medicine in 2019. Past research support includes funding from the National Institute for Occupational Safety and Health (NIOSH). She is an Editorial Board Member of the Journal of Aging and Health and has served as an editorial peer reviewer for many other journals. She is a member of the European Association for Population Studies.

She holds a Ph.D. in Public Health from the University of Connecticut, MPH from West Virginia University, and a B.A. in International Studies from West Virginia University.