Prior to her doctoral work, Masingila taught secondary mathematics for six years. Her research interests include teacher development, teacher educator development, mathematical knowledge for teaching teachers, and students’ out-of-school mathematics practice.

She is or has been a principal investigator or co-principal investigator for over $7 million in grants, including six from the National Science Foundation and two from the United States Agency for International Development. Masingila has published widely in journals and books, and has developed a number of multimedia case studies examining issues in teaching practice.