Wilson is Principal Investigator on the , a research & demonstration project that develops low-carbon design approaches that integrate energy, human health, and life cycle criteria for affordable housing. Wilson advises PhD, Master of Science, Master of Architecture, and Bachelor of Architecture thesis students, and teaches sustainable building technology and design research courses at the Syracuse University School of Architecture. She operates her interdisciplinary research lab as a Faculty Research Fellow from the Syracuse Center of Excellence.

Sho is a partner and co-founder of nonprofit architecture firm  (GAC) that works with underrepresented communities to build aesthetically engaging spaces while using the construction sites for end-user training. GAC’s work includes self-build homes funded by the 2012 Arnold Brunner Grant, which received the 2014 EDRA Great Places Award; the Masoro Health Center, which was recognized by AIA Virginia, Dezeen, Architizer, SARA NY and Architecture Masterprize in 2020; and the Masoro Learning and Sports Center in 2021, which has been recognized by SARA NY, ArchDaily, Dezeen and Architizer. GAC is currently working on the masterplan and design of 22-acre campus for Kigali International Community School, Rwanda Housing Project to survey and document 370 rural homes with architecture students from University of Rwanda and Syracuse, among others. GAC was the recipient of Best of Practice Award for Architect (Small Firm) in the Northeast by The Architect’s Newspaper in 2021 and was named the Game Changers by Metropolis magazine in 2020.

As Chancellor’s Fellow in the Humanities (2011-14) his annual seminar and ongoing event series focused on imaging theories and the ways that the precise analysis, application, and understanding of images invite innovative research methods and collaborations. A website, , documents the results of that work and subsequent courses. Most recently, his in multi-media installation, NeuroArchitectureImaging (2019), explored intersections of imaging practices in architecture and neuroscience. A prior long term transdisciplinary project (2000-2015) investigated the potential of Geographic Information Systems as an urban design media with the capacity to transform census and other data, with its discrete categories and boundaries, into more pliable, or fluid, relational images that can suggest new spatial densities, intensities, gaps, affiliations, networks, communities, and territories. His most recent GIS project was exhibited at McGill University in 2012 and the Cleveland Urban Design Collaborative in 2015.